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synthesis and molecular docking studies of some tetrahydroimidazo[1,2-a] pyridine derivatives as potent α-glucosidase inhibitors
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نویسنده
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asghariganjeh mohammad r. ,rayatzadeh ayeh ,tahanpesar elham ,mohammadi ali a. ,makarem somayeh
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منبع
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journal of applied chemical research - 2021 - دوره : 15 - شماره : 1 - صفحه:24 -35
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چکیده
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Kal(so4)2.12h2o is found to efficiently and heterogeneously catalyze the one-pot three-component reaction of 2-(nitromethylene)imidazolidine, malononitrile and aldehydes under mild conditions to afford the corresponding tetrahydroimidazo[1,2-a]pyridine in good yields and short reaction times. docking study of some compounds in the active site of α-glucosidase demonstrated that these compounds interacted with important active site residues with low binding energy in comparison to standard inhibitor acarbose.
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کلیدواژه
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alum ,three-component reactions ,tetrahydroimidazo [1 ,2-a]pyridine ,molecular docking studies ,α-glucosidase
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آدرس
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islamic azad university, khuzestan science and research branch, department of chemistrydepartment of chemistry, iran. islamic azad university, ahvaz branch, department of chemistry, iran, islamic azad university, ahvaz branch, department of chemistry, iran, islamic azad university, ahvaz branch, department of chemistry, iran, islamic azad university, ahvaz branch, department of chemistry, iran. chemistry and chemical engineering research center of iran (ccerci), iran, islamic azad university, karaj branch, department of chemistry, iran
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پست الکترونیکی
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s_makarem@sbu.ac.ir
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Authors
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