Promoted Preparation of Aminophosphonate and Functionalized Coumarins Derivatives as Key Constituent of Many Pharmaceutical Compounds

The reaction between trialkyl phosphites with dialkyl actylenedicarboxylates in the presence of 2-hydroxyquinoline (2-quinolinol) leads to β-aminophsphonates derivatives which they have manyapplications in medicinal chemistry. when the reaction was performed by triphenylphosphite, a newpyrano quinoline compounds were obtained in fairly good yields. these compounds also providebiologically interesting. all products were established by ir, nmr (^1h, ^13c and ^31p),mass spectroscopy and elemental analysis.