One-pot Synthesis of Amidoalkyl Naphthol Derivatives as Potential Nucleoside Antibiotics and HIV Protease Inhibitors using Nano-SnO2 as an Efficient Catalyst

An efficient three-component one-pot synthesis of 1-amidoalkyl-2-naphthols from 2-naphthol,aldehydes, and acetamide using nano-sno2as catalyst is described. the reactions were carried out at 80ºc under water-solvent media. the structures of the compounds were characterized by ir, ^1hnmr, ^13c-nmr, and mass spectra and by elemental analysis. the advantages of the effectivemethod were good yields, short reaction times, simple work-up, eco-friendly solvent, andinexpensive and reusable catalyst. the catalyst could be recycled and reused for five times withoutmuch loss in its activity.