A Simple and an Effective Catalyst for Determination of Cefixime in Real Samples Using of Modified Carbon Paste Electrode with Cobalt Impregnated Zeolite

Carbon paste electrode modified with cobalt impregnated zeolite was prepared by mixing ofcobalt_zeolite (co_z) and graphite powder with different percent. the electrochemical oxidation ofcefixime at such electrodes was investigated using the cyclic voltammetric and amperometrictechniques. it is not electrochemically active towards cefixime oxidation in 0.1 m phosphate buffersolution (ph=7) on a carbon paste electrode modified with zeolite. the presence of cobalt ions inthe zeolite matrix, by soaking the electrode in an aqueous co(no3)2 solution, markedly enhancesthe electrocatalytic activity which was found to depend on the cobalt content. however, theelectrocatalytic activity depends on different percent of co_z. under the selected conditions, theanodic peak current was linearly dependent on the concentration of cefixime in the range 0.003–8mm with the cyclic voltammetric method. the detection limit (s/n=3) was also estimated to be2.98 μm. finally, this method was applied for the determination of cefixime in tablet samples.