Solvent-free Biginelli Reaction Catalyzed to Synthesis of Biologically Active 3,4-dihydropyrimidin-2-(1H) –ones/ thiones Derivatives

A convenient and highly efficient procedure for the synthesis of 3,4-dihydropyrimidin-2-(1h)- one/thione derivatives via one-pot three-component biginelli condensation of aryl aldehydes,urea/thiourea and ethyl/methyl acetoacetate in the presence of znso4.7h2o as an efficient, readily and inexpensive catalyst under solvent-free conditions have been studied. this protocol has advantages such as readily available and non-toxic catalyst, short reaction times, good to high yields, solvent-free conditions, facile reaction profiles, high atom-economy and simple work-up.