Application of Nicotinic Acid Functionalized Chlorosulfonic Acid as a Green Catalyst for the Synthesis of Bis(2-methyl-1Hindole) Derivatives

3-carboxy-1-sulfopyridin-1-ium chloride ([cpyso3h]^+cl^-) as a novel ionic organocatalyst for the condensation of aldehydes and 2-methylindole to synthesize bis(2-methyl-1h-indole) derivatives in acetonitrile at room temperature has been developed. some tetrakis (2-methyl-1h-indole) derivatives have also been synthesized by the reaction of 2,2'-(butane-1,4- diylbis(oxy))dibenzaldehyde and 2-methylindole or indole in the presence of chlorosulfonic acid immobilized on nicotinic acid ([cpyso3h]^+cl^-) at room temperature. all products formed in excellent yields over short reaction times under mild and environmentally friendly conditions. this methodology offers significant improvements for the synthesis of bis(2-methyl-1h-indole) derivatives with regard to the yield of products, simplicity in operation and reusability of the catalyst.