Reactions of 2,4-dioxo-4-phenylbutanoates With Dinucleophiles in Mild Condition

Benzoylpyruvic ester reacts with dinucleophiles 1,2-diaminoarenes, 2-aminohydroxyarenes, 2,3-diaminopyridine, 1,2-ethylenediamine, and 1,2-diaminocyclohexane to form the corresponding quinoxaline, 1,4-benzoxazine, and pyrazine derivatives. a facile synthesis of substituted quinoxalines and 1,4-benzoxazines catalyzed by nahso4 at room temperature reaching very high yields is reported. the structure of the resulting products was confirmed by determination of the melting point and spectrophotometric techniques such as ir and 1h-nmr, and in some cases using 13c-nmr spectroscopy.