A Novel Method for Quantitative Determination ofAceclofenac in Bulk Drug and Tablets Using IbuprofenSodium as a Hydrotropic Solubilizing Agent

Hydrotropic solubilization phenomenon has been widely used to enhance the aqueous solubility of a large number of poorly water-soluble drugs. various organic solvents like methanol, chloroform, dimethyl formamide and ethanol have been employed for solubilization of poorly water-soluble drugs to conduct their titrimetric analysis.drawbacks of organic solvents include their higher cost, toxicities and pollution. in the present investigation a 0.5 m ibuprofen sodium solution (an economic agent) was employed as a hydrotropic solubilizing agent to solubilize the poorly water-soluble drug,aceclofenac, for its titrimetric analysis in bulk sample and tablets precluding the use of organic solvent. the proposed method is new, simple, precise and inexpensive. the results of the analysis have been validated statistically. the mean % recoveries were found to beclose to 100, indicating the accuracy of the proposed method. low values of standard deviation, % coefficient of variation and standard error further proved the reproducibility and precision of the proposed method.