the effects of 10-week aerobic-cognitive combined training on serum levels of high sensitivity c-reactive protein, anti-cardiolipin antibodies, and mental status of female patients with lupus erythematosus systemic: a preliminary study

Introduction: physical training, especially aerobic exercise combined with mental training by patients with systemic lupus erythematosus (sle), has numerous benefits, including tissue generation and enhanced anti-inflammatory activity. this study aimed at investigating the effect of ten-week aerobic-cognitive combined training on the serum levels of high sensitivity c-reactive protein (hs-crp), anti-cardiolipin antibodies, immunoglobulin g (igg), immunoglobulin m (igm), and mental status of female sle patients. materials and methods: eight female patients with sle (with the mean±sd age of 50±47.04 year and the mean±sd bmi of 29.57±5.83 kg/m2) were randomly assigned to the experimental (n=5) and control (n=3) groups. the experimental group performed brailletonik exercise, including aerobic (60-80% of max hr) and cognitive training for ten weeks. the serum levels of hs-crp, igg, igm, and mental status of the patients were evaluated in both groups before and after the training. results: according to the results of 2×2 mixed analysis of covariance (ancova), there was no significant effect of training on the serum levels of hs-crp, igg, and igm (p>0.05), but hscrp and igm level decreased in the experimental group by (42%) and (23.5%), respectively. the result of ancova indicated the significant effect of training on mental status (p=0.005). conclusion: physical combined cognitive training could be more effective in improving the mental status compared to a decrease in serum inflammatory factors of sle patients.