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Use of recombinant factor VIIa in uncontrolled gastrointestinal bleeding after hematopoietic stem cell transplantation among patients with thrombocytopenia
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نویسنده
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tang y. ,wu q. ,wu x. ,qiu q. ,sun s. ,ruan r. ,wu d. ,han y.
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منبع
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pakistan journal of medical sciences - 2015 - دوره : 31 - شماره : 6 - صفحه:1389 -1393
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چکیده
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Background and objective: recombinant-activated factor vii (rviia) is a vitamin k-dependent glycoprotein that is an analog of the naturally occurring protease. it has an off-label use to control life-threatening bleeding that is refractory to other measures and was shown to decrease transfusion requirements. gastrointestinal (gi) bleeding is a severe complication following hematopoietic stem cell transplantation (hsct) in patients with thrombocytopenia,while hemostatic measures based on antifibrinolytic or transfusion therapy may not always be successful. the present study investigated the treatment with rfviia in severe gi bleeding among thrombocytopenia patients undergoing hsct. methods: rfviia was given as a single dose of 60μg/kg in patients with gi bleeding following hematopoietic stem cell transplantation (hsct). results: among all patients enrolled,12 (75%) of 16 patients obtained a response,of which 5 achieved a complete response and 7 achieved a partial response. the 4 remiaing patients (25%) had no response. nine patients (56.3%) died in a follow-up of 90 days. no thromboembolic events wereassociated with the drug administration occurred. conclusions: our study showed that rfviia may represent an additional therapeutic option in such cases. © 2015,pakistan journal of medical sciences. all rights reserved.
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کلیدواژه
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Gastrointestinal bleeding; Hematopoietic stem cell transplantation; Hemostatic treatments; Recombinant factor VIIa; Thrombocytopenia
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آدرس
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jiangsu institute of hematology,key laboratory of thrombosis and hemostasis of ministry of health,the first affiliated hospital of soochow university,suzhou,china,collaborative innovation center of hematology,soochow university, China, jiangsu institute of hematology,key laboratory of thrombosis and hemostasis of ministry of health,the first affiliated hospital of soochow university,suzhou,china,collaborative innovation center of hematology,soochow university, China, jiangsu institute of hematology,key laboratory of thrombosis and hemostasis of ministry of health,the first affiliated hospital of soochow university,suzhou,china,collaborative innovation center of hematology,soochow university, China, jiangsu institute of hematology,key laboratory of thrombosis and hemostasis of ministry of health,the first affiliated hospital of soochow university,suzhou,china,collaborative innovation center of hematology,soochow university, China, jiangsu institute of hematology,key laboratory of thrombosis and hemostasis of ministry of health,the first affiliated hospital of soochow university,suzhou,china,collaborative innovation center of hematology,soochow university, China, jiangsu institute of hematology,key laboratory of thrombosis and hemostasis of ministry of health,the first affiliated hospital of soochow university,suzhou,china,collaborative innovation center of hematology,soochow university, China, jiangsu institute of hematology,key laboratory of thrombosis and hemostasis of ministry of health,the first affiliated hospital of soochow university,suzhou,china,collaborative innovation center of hematology,soochow university, China, jiangsu institute of hematology,key laboratory of thrombosis and hemostasis of ministry of health,the first affiliated hospital of soochow university,suzhou,china,collaborative innovation center of hematology,soochow university, China
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Authors
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