Expressions and clinical significance of serum bone Gla-protein, bone alkaline phosphatase and C-terminal telopeptide of type I collagen in bone metabolism of patients with osteoporosis

Objective: this study aimed to evaluate the expressions and clinical significance of bone gla-protein (bgp), bone alkaline phosphatase (b-alp) and c-terminal telopeptide of type i collagen (ctx) in patients with osteoporosis (op), and to provide evidence for developing individualized treatment plans. methods: seventy-two op patients in our hospital were selected as an op group, and another 72 healthy subjects were used as a control group. their bgp, b-alp and ctx levels as well as bone mineral density (bmd) values were measured. the correlations between bgp, b-alp and ctx levels and bmd values were determined. results: the bgp level of the op group [(5.61±5.52) ng/ml] was significantly higher than that of the control group (p<0.05), but the levels of b-alp and ctx did not differ significantly (p>0.05). the bmd values of femoral neck and ward’s triangle in the op group were negatively correlated with the b-alp levels (p<0.05). for women op patients, the bmd values of femoral neck and ward’s triangle were also negatively correlated with the b-alp levels (p<0.05). the bmd of femoral neck in the control group was negatively correlated with the ctx level (p<0.05). conclusion: determining bgp, b-alp and ctx levels can evaluate the bone metabolism degree, which provides evidence for clinical typing of op and developing treatment strategies.