Effects of glutamine and valsartan on the brain natriuretic peptide and N-terminal pro-B-type natriuretic peptide of patients with chronic heart failure

Objective: to analyze the effects of glutamine and valsartan on the brain natriuretic peptide (bnp) and n-terminal pro-b-type natriuretic peptide (nt-probnp) of patients with chronic heart failure (chf). methods: a total of 140 chf patients were divided into a treatment group and a control group by random drawing, and were subjected to standard anti-heart failure treatment and administered with valsartan. besides, the treatment group was also intravenously transfused glutamine. the treatment lasted eight weeks. results: the overall efficacy of treatment group and control group were 98.6% and 90.0% respectively, with a statistically significant difference (p<0.05). the two groups had significantly increased left ventricular ejection fractions as well as significantly decreased left ventricular end-diastolic volumes and left ventricular end-diastolic dimensions after treatments (p<0.05) compared with those before. there were also inter-group differences between these values (p<0.05). after treatment, the levels of bnp, nt-probnp and cd8+ in both groups significantly decreased (p<0.05), whereas those of cd4+ significantly increased (p<0.05). the two groups also had significantly different values (p<0.05). conclusion: glutamine in combination with valsartan enhanced the therapeutic effects by improving cardiac function, which may be associated with decreased expressions of bnp and nt-probnp and beneficial effects of glutamine on immune function.