Pernicious anemia in patients with macrocytic anemia and low serum B12

Objective: the current research evaluated the prevalence of pernicious anemia (pa) in patients with macrocytic anemia (high mcv) and low serum b12 in riyadh. methods: blood testing was done in 77 patients (males: 45.5%, females: 54.5%) with macrocytic anemia; 84 patients; (males: 23.8%, females: 76.2%) with low serum b12 and 30 healthy subjects. complete blood count, differential count, folic acid, vitamin b12, intrinsic factor, gastric parietal cell antibodies and holotranscobalamin ii were assessed. results: a total of five subjects from 161 patients had pa; three of these patients had macrocyticanemia (3.90%) and two patients had low serum b12 (2.38%). significant differences (p<0.05) in some hematological, immunological, biochemical parameters were found in subjects with macrocytic anemia and low serum b12 compared to controls. conclusions: pernicious anemia in patients with macrocytic anemia and low serum b12 was for the selected sample size can be assumed to be uncommon in riyadh, saudi arabia.