Association between polymorphisms in IL-16 genes and coronary heart disease risk

Objective: we aimed to investigate the role of polymorphisms in il-16 genes on the susceptibility of coronary artery disease (cad). methods: a total of 260 cad cases and 281 health controls were collected between january 2008 and november 2011. genotyping of il-16 rs8034928, rs3848180, rs1131445, rs4778889 and rs11556218 was conducted by polymerase chain reaction (pcr) and matrix-assisted laser desorption/ionization time-offlight (maldi-tof) mass spectrometry technologies. results: the frequencies of rs8034928 c allele and rs3848180 g allele in the cad cases in cad group were significantly higher than in controls. compared with rs8034928 t/t genotype, a significant higher risk of cad was found in c/c genotype (or=1.87, 95%ci=1.17-3.03), and variant of rs8034928 showed a significant increased risk of cad in dominant (or=1.48, 95%ci=1.04-2.10) and recessive model (or=1.70, 95%ci=1.10- 2.67). the rs3848180 g/g was found to be associated with risk of cad(or=1.79, 95%ci=1.16-2.75), and g allele carries had a significant risk of cad (or=1.47, 95%ci=1.02-2.13). conclusions: our study indicated that rs8034928 and rs11556218 polymorphisms are associated with cad risk in a chinese population, and il-16 gene polymorphisms may be used as a predictor to the susceptibility of cad.