Meta-Analysis of ABCB1 3435C>T Polymorphism and Colorectal Cancer

Objective: many studies have focused on the association between the abcb1 3435c>t polymorphism and colorectal cancer (crc) risk. however, the results were conflicting. the aim of this meta-analysis is to evaluate the precise association between this polymorphism and crc risk. methods: we formally reviewed the literature at pubmed, embase and the cochrane library with the key words as follows: abcb1/mdr1/p-glycoprotein, polymorphism, colorectal and cancer/neoplasm/tumor. this meta-analysis was assessed by review manager 5.0. the fixed-effects model was used to pool the odds ratios (or) with 95% confidence intervals (ci) for crc risk. results: there were 8 studies identified. the pooled or with 95% ci of cc+ct versus tt genotype of the abcb1 3435c>t polymorphism for crc risk was 1.01 [0.90-1.13]. the sensitivity analysis further confirmed the result. heterogeneity and publication bias were not observed in this meta-analysis. conclusions: in summary, there was no significant association between the abcb1 3435c>t polymorphism and crc risk.