Association between CC10 +38A/G polymorphism and asthma risk: A meta-analysis

Objectives: a number of studies conducted to assess the association between clara cell 10-kda protein (cc10) +38a/g polymorphism and susceptibility to asthma have yielded inconsistent and inconclusive results. in the present study, the possible association was assessed by a meta-analysis. methods: relevant articles were identified for the period ranging from jan 1998 up to march 2013. pooled odds ratios (or) with 95% confidence intervals (ci) were appropriately derived from fixed effects or randomeffects models. results: ten case-control studies with a total of 1529 asthma cases and 2399 controls were included in this meta-analysis. the association between cc10 +38a/g polymorphism and asthma risk was determined in dominant model, recessive model, additive model, and codominant model. in dominant model, cc10 +38a/g polymorphism seemed to be associated with elevated asthma risk (or = 1.62; 95% ci, 1.23 -2.12; p = 0.0005). subgroup analyses by ethnicity also found significant associations between this polymorphism and asthma risk in asians and caucasians. results from other genetic models further identified this possible association. conclusion: this meta-analysis suggests that cc10 +38a/g polymorphism confers asthma risk.