Abnormal Lipid levels as a risk factor of eclampsia, study conducted in tertiary care Hospitals of Khyber Pakhtunkhwa Province - Pakistan

Objective: to evaluate abnormal lipid metabolism as a risk factor of eclampsia in pregnant women. methods: this cross sectional study was conducted in three tertiary care hospitals of peshawar. serum total cholesterol (tc), high density lipoprotein cholesterol (hdl-c), low density lipoprotein cholesterol (ldl-c), very low density lipoprotein cholesterol (vldl-c), triglyceride (tg), apolipoprotein a1 (apo-a1), apo-b100, lipoprotein-a (lpa) were measured in 110 women with eclampsia and compared with 90 healthy pregnant women. mean lipid levels in cases and controls were compared using student’s t test”. results: mean systolic/diastolic blood pressure, tc, tg, vldl-c and lpa levels were significantly higher (p < 0.001) in patients compared to control women. similarly tc: hdl-c, ldl-c: hdl-c and tg: hdl-c ratio in the patients group were significantly higher (p < 0.001) and hdl-c: vldl-c ratio was significantly lower (p < 0.001) in the patients as compared to control group. undesirable cholesterol were noted in 35.8% patients, hdl-c in 50.5%, borderline high concentration of ldl-c in 23.6%, high triglycerides levels in 73.2%, undesirable cholesterol ratio in 52.3% and undesirable ldl-c ratio were noted in 82.1% patients of eclampsia. conclusion: serum lipids were found significantly higher thus early assessment may be helpful in prevention of complications in the eclampsia patients.