The impact of Vitamin D replacement on Glucose Metabolism

Objective: we investigated the impact of vitamin d supplementation on glucose metabolism in vitamin d-deficient patients with prediabetes. methods: a total of 66 subjects with the mean ages 52.2±9.9 years were included in this prospective and a 6-month follow-up study between 2008-2010. vitamin d deficient patients ( < 25ng/ml) were supplemented with oral vitamin d. results: vitamin d deficiency ( < 25ng/ml) was found in 93.9% of the patients. post replacement vitamin d levels increased significantly and insulin, hba1c, and homa-ir decreased significantly following vitamin d replacement. conclusion: we found vitamin d deficiency was very common in our study population. in vitamin d deficient patients, supplementation treatment improved insulin resistance and glycemic parameters. vitamin d replacement may be a promising intervention for the primary prevention of insulin resistance syndromes.