The polymorphism of Insulin-like growth factor-I (IGF-I) is related to osteoporosis and bone mineral density in postmenopausal population

Objective: it has been shown that insulin-like growth factor-1 (igf-1) may be related with bone mineral density (bmd) or osteoporosis. but there are few evidences on the role of genetic variation of igf-1 on the bmd or osteoporosis. we observed the relationship between polymorphisms of igf-1(rs35767, rs2288377 and rs5742612) with osteoporosis and bmd in the postmenopausal female population in our study. methods: a total of 216 postmenopausal women with a primary diagnosis of osteoporosis and 220 normal healthy women were included in the study. genomic dna of igf-1 rs35767, rs2288377 and rs5742612 was extracted from the whole blood using qiaamp blood dna mini kits (qiagen, hilden, germany) according to the methods recommended by the manufacturer. results: we found that t allele of rs35767 had higher increased risk of osteoporosis (or=1.34, 95%ci=1.0- 1.81). those carrying t allele of rs35767 had a significant lower bmd at l1–l4 vertebrae, femoral neck, total hip and trochanter when compared with those carrying c allele (p < 0.05). in addition, the bmd of l1–l4 vertebrae, femoral neck, total hip and trochanter decreased by 2.09%, 3.74%, 3.52% and 2.54% in women carrying t alleles compared with those carrying c alleles. conclusion: our study suggests that polymorphism in igf-i rs35767 was significantly associated with bmd and osteoporosis in postmenopausal female population, and polymorphism of rs35767 could be a marker for lower bmd and risk of osteoporosis.