Effect of ABCB1 polymorphism on the clinical outcome of osteosarcoma patients after receiving chemotherapy

Objective: to investigate the role of three genetic polymorphisms of abc proteins in response to chemotherapy and overall survival of osteosarcoma patients. methods: a prospective study was conducted. genotyping analyses of abcb1 c3435t, abcg2 c421a, and abcc3 c-211t were conducted using the taqman methodology. multivariate cox proportional hazards models were used to calculate hazard ratio (hr) and 95% ci of effect of each genotype of abcb1 c3435t, abcg2 c421a, and abcc3 c-211t on pfs and os. results: during the follow-up period, 135 patients (74.18%) were alive and 47 died (25.82). the median follow-up periods were 36.7 months. individuals carrying with abcb1 3435tt genotype and t allele showed less likely to have a poor response to chemotherapy. cox regression analysis showed that individuals with abcb1 tt genotype and t allele were associated with high risk of death from osteosarcoma when compared with wide-type genotype. however, we did not find significant association between abcg2 c421a and abcc3 c-211t polymorphisms and overall survival of osteosarcoma. conclusion: abcb1 c3435t polymorphism may be used as a genetic predictor of clinical outcome in osteosarcoma patients treated with chemotherapy. however, no association was found between polymorphisms in abcg2 c421a and abcc3 c-211t and clinical outcome of osteosarcoma.