Clinical effects of soluble interleukin-6 receptor detection on autoimmune rheumatic disease patients

Objective: this study aims to explore the effects of soluble interleukin-6 receptor (il-6r) on the clinical diagnosis and treatment of autoimmune rheumatic disease (ard) patients. methods: sixty-eight ard patients enrolled in our hospital recently were selected, the il-6r levels of whom were detected by double-antibody sandwich elisa method and compared with the il-6 levels of normal subjects. the expressions of il-6r in joint tissues were detected by section staining. the mechanism regarding the effects of il-6r was postulated by administering the patients with blocking agent. results: the blood il-6r level of ard patients was 2-3 times higher than the il-6 level of normal subjects with significant difference. the detection results of c-reactive protein and erythrocyte sedimentation rate show that both the indicators were significantly decreased (p=0.0098 and 0.0097 respectively). il-6r was associated with autoimmunity based on the considerable expression in tissue sections, which was also verified by the alleviated symptoms after blocking il-6r expression. conclusion: detecting soluble il-6r is able to determine the patient’s conditions and treatment effects. meanwhile, soluble il-6r detection can also serve as the inflammatory responses of ard, as well as the determination index for abnormal immune responses and generated antibodies number, which is crucial for early diagnosis.