The terminator “Non-sense mediate mRNA decay”: Its role in the termination of intron containing a premature termination codon

Human genes are composed of exons and interrupted by introns that must be removed by splicing to create a translatable mrna. alternative splicing is a vital pathway to regulate gene expression and increase the protein diversity. in addition to skipping and inclusion of variable exons and usage of alternative splice sites, intron retention is a third example of alternative splicing, whereby an intron sequence is retained or skipped in the mature mrna transcript.