25-Hydroxyvitamin D is closely related with the function of the pancreatic islet β cells

Objectives: this study is to investigate the relationship between 25-hydroxyvitamin d (25-oh-d) andpancreatic islet β cell function under different glucose tolerance statuses in china. methodology: totally, 180 patients with type 2 diabetes mellitus (dm group), 178 patients with impaired fasting glucose/impaired glucose tolerance (ifg/igt group), and 160 normal control subjects (ngt group) were included to measure their body parameters and biochemical parameters. in oral glucose tolerance test, fasting serum 25-oh-d was assessed by the enzyme-linked immunosorbent assay (elisa). homeostasis model assessment for insulin resistance (homa-ir), insulin acuity index (iai), β-cell function index (homa- bcf) as well as secretion index (is) were determined. results: the levels of 25-oh-d, iai and homa-bcf in the dm group and ifg/igt group were significantly lower than that in ngt group (p < 0.05). homa-ir in dm group and ifg/igt group was significantly higherthan that in the ngt group (p < 0.05). pearson correlation analysis and partial correlation analysis showed that 25-oh-d was positively correlated with fasting insulin (fins) and homa-bcf (p < 0.05). multiple stepwise regression analysis showed that 25-oh-d was one of the influential factors of pancreatic islet β cell function in patients with type 2 diabetes mellitus. conclusions: our results suggest that 25-oh-d is closely related with the function of the pancreatic islet β cells and is one of the influential factors of pancreatic islet β cell function