Association between neurological and rheumatological manifestations in vitamin D deficiency and vitamin D levels

Objective: we aimed to investigate the associations between the neurological manifestations of vitamin d deficiency and bone profile as well as the levels of 25-hydroxyvitamin d. methodology: we conducted a case series on patients with vitamin d deficiency who were followed up at king abdulaziz medical city, jeddah between january 2010 and december 2011. we collected patients’demographic data and gathered information on etiological factors for vitamin d deficiency as well as clinical presentations (typical, neurological and rheumatological) and radiological findings. the t-test was used to determine whether there was an association between the neurological manifestations of vitamin d deficiency and vitamin d levels and bone profile. results: we enrolled 60 patients with vitamin d deficiency. of these, 44 (73.3%) had neurological presentations, namely progressive muscle weakness and proximal weakness, which was observed more often than distal weakness. in addition, gait disturbances were observed in 61.7% of all patients with neurological and rheumatological presentations. there was no significant association between neurological and rheumatological manifestations and bone profile or vitamin d levels. we found a significant association between difficulty in walking and the levels of serum calcium and phosphate (p = 0.043 and 0.037, respectively).conclusion: neurological and rheumatologic manifestations of vitamin d deficiency are not associated with 25-hydroxyvitamin d levels or bone profile