The effects of serum cholesterol, LDL, and HDL levels on gallstone cholesterol concentration

Objective: gallbladder stones are common in the western world, and 70% to 80% of gallstones are cholesterol stones. this study investigates the effects of serum cholesterol, ldl, and hdl levels on gallstone cholesterol concentration.methodology: the gallstones of 75 patients with cholelithiasis were examined using spectrophotometry.results: high serum cholesterol and ldl levels were associated with high cholesterol stone rates (86.7% vs. 40.0%, p < 0.001; 75.0% vs. 48.9%, p < 0.05, respectively). similarly, high serum cholesterol and ldl levels were correlated with high gallbladder stone cholesterol concentrations (63.6% vs. 44.4%, p < 0.001; 62.3% vs. 46.0%, p < 0.001, respectively). in contrast, low serum hdl levels do not seem to affect the occurrence of gallbladder cholesterol stones (60.0% vs. 58.3%, respectively, p > 0.05) or gallbladder stone cholesterol concentrations (50.8% vs. 52.4%, respectively, p > 0.05).conclusion: the relationship between cholesterol, ldl, and hdl levels and cholesterol gallstone formation is multifactorial and complex and is also dependent on other individual properties