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Immunosuppressive effects of Rifampicin on a tuberculosis patient after renal transplant
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نویسنده
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Wang WG ,Wang YT ,Zhou HL ,Li P ,Wang G ,Gao BS ,Fu YW
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منبع
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pakistan journal of medical sciences - 2011 - دوره : 27 - شماره : 3 - صفحه:720 -722
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چکیده
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Rifampicin is a semisynthetic derivative of rifamycin b and inhibits the growth of a variety of bacteria. rifampicin causes an increase in corticosteroid clearance, and a decrease in the blood concentrations of calcineurin inhibitors by inducing cytochrome p450 3a4 in the liver. it is generally acknowledged that a substantial increase in the dosage of calcineurin inhibitors is required to achieve the efficacious target concentrations and avoid graft rejection. we report a case of patient who received a living-related donor renal transplant with stable renal function during the rifampicin based anti-tuberculosis treatment, even the blood concentration of tacrolimus (fk506) decreased. interestingly, acute rejection was observed at the end of anti-tuberculosis treatment, even the blood concentration of fk506 was reduced to target level.
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کلیدواژه
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Rifampicin ,Tuberculosis ,Renal transplant ,Immunosuppression.
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آدرس
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Jilin University, First Bethune Hospital, Urinary Diseases Diagnosis & Treatment Center, China, Jilin University, First Bethune Hospital, Urinary Diseases Diagnosis & Treatment Center, China, Jilin University, First Bethune Hospital, Urinary Diseases Diagnosis & Treatment Center, China, Jilin University, China-Japan Union Hospital, Department of Rheumatology, China, Jilin University, First Bethune Hospital, Urinary Diseases Diagnosis & Treatment Center, China, Jilin University, First Bethune Hospital, Urinary Diseases Diagnosis & Treatment Center, China, Jilin University, First Bethune Hospital, Urinary Diseases Diagnosis & Treatment Center, China
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Authors
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