Association of genetic polymorphisms at the glutathione S-transferase Pi locus with prostate cancer

Objective: the present report evaluates a possible association of the gst-pi ile105val polymorphism with sporadic prostate cancer. methodology: tissue samples from 35 prostate adenocarcinomas and 26 geographically and age matched benign prostatic hyperplasia (bph) patients as control subjects were tested for gst-pi polymorphism by using restriction fragment length polymorphism (rflp) method for the polymerase chain reaction (pcr) product. results: among prostate carcinoma patients, 60% were homozygous for the wild type allele (ile/ile), 22% for heterozygous (ile/val) and 18% homozygous for mutant allele (val/val). while, the control group showed 64% of the subjects were homozygous for wild type allele, 28% were heterozygous and 8% homozygous for mutant allele. conclusion: val/val genotype of gst-pi was significantly connected with prostate cancer risk, hence, gst-pi polymorphism may take part in developing prostate cancer.