STUDY ON HLA-DQB1 *03 ALLELE ASSOCIATED WITH WOMEN HUMAN PAPILLOMA VIRUS HPV) LESIONS

Objectives: the specific hla alleles associated with hpv differ among various study groups. it has been suggested that women carrying hla-dqw3 antigen encoded by dqb 1*03, are predisposed to develop cervical cancer. the aim of this study was to determine hla-dqb1*03 alleles in hpv lesions. methodology: in a cross-sectional and analytical study, hundred women enrolled into the study. twenty of them had abnormal pap smear, fifty patients had condyloma lesions and 30 patients with malignant lesions. hla–dqb*03 and hpv infection was evaluated by pcr. results: pcr of hpv was positive in 50 women with condyloma lesions and 8 women with malignant lesion (p< 0.001). hla–dqb*03 was positive in 9 women with abnormal pap smear , 18 women with condyloma lesions and 7 women with malignant lesion(p= 0.261). positive pcr of hpv was significantly higher in women with condyloma lesions than other women (p< 0.001). mean age of patients with positive pcr of hpv was significantly lower than patients with negative pcr of hpv (p= 0.001). mean age of patients with positive hla–dqb*03 was 42.08 + 11.48 year and mean age of patients with negative hla–dqb*03 was 43.83 +11.21 year (p= 0.462). hla–dqb*03 was positive in 34% of patients. conclusion: in this study, we do not see any significant correlation between hpv infection and hla–dqb*03 in the studied women.