Alanine aminotransferase as a predictor of adverse perinatal outcomes in women with intrahepatic cholestasis of pregnancy

Objective: to evaluate the associations between adverse perinatal outcomes and serum transaminase levels at the time of diagnosis in patients with intrahepatic cholestasis of pregnancy. methods: we performed a retrospective analysis of patients hospitalized for evaluation of intrahepatic cholestasis of pregnancy from january 2013 to june 2014 in a tertiary center. seventy-one patients were divided into two groups according to the presence (group i) or absence of adverse perinatal outcomes (group ii). results: the mean aminotransferase levels and conjugated bilirubin levels at the time of diagnosis were significantly higher in group i than in group ii. receiver operating characteristic curve analysis revealed that the alanine aminotransferase level could predict adverse perinatal outcomes with 76.47% sensitivity and 78.38% specificity,and the cut-off value was 95 iu/l.among patients with intrahepatic cholestasis of pregnancy,those with adverse perinatal outcomes were significantly older,had an earlier diagnosis,and had higher alanine aminotransferase levels. using the 95-iu/l cut-off value,patients with intrahepatic cholestasis of pregnancy had a 3.54-fold increased risk for adverse perinatal outcomes. conclusions:patients with intrahepatic cholestasis of pregnancy and high alanineaminotransferase levels should be followed up for possible adverse perinatal outcomes. © 2016,professional medical publications. all rights reserved.