Intravenous ketamine,propofol and propofol-ketamine combination used for pediatric dental sedation: A randomized clinical study

Background and objective: dental treatments cannot be always performed under local anesthesia in pediatric non-cooperative patients. for this purpose,different anesthetic techniques have been applied to increase patient comport to dental treatments. methods: sixty children classified as asa i-ii,between aged 3 to 9,who were scheduled to undergo tooth extraction,were enrolled for this randomized study. group k received 1 mg/kg ketamine,group p received 1 mg/kg propofol,and group kp received 0.5 mg/kg propofol plus 0.5 mg/kg ketamine intravenously for anesthesia induction. results: recovery time was significantly lower in group p than group kp. no significant differences were found between groups regarding hr,before and after the induction,at tenth minute. fifth minute’s hr was higher in group k than group kp. mean arterial pressure (map) values were similar at baseline,before and after the induction,and at tenth minute,whereas significantly lower values were found in group p and group kp than in group k at fifth minute. conclusions: although ketamine,propofol and ketamine-propofol combination are effective for sedation in tooth extraction in pediatric patients,propofol may be an excellent alternative,with the shortest recovery,no nausea and vomiting,and reasonable surgical satisfaction. © 2016,professional medical publications. all rights reserved.