Correlation of CD24 expression with histological grading and TNM staging of retinoblastoma

Objective: correlation of cd24 expression with histological grading and tnm staging of retinoblastoma. methods: this cross-sectional study was conducted in the department of pathology,bmsi,jpmc and nich from 1st january 2009 to 31st december 2013. a total 68 diagnosed cases of retinoblastoma were selected for cd24 immuno staining. the data was analyzed by using spss version 22. results: out of 68 cases 7.35% showed grade 1 followed by 11.76% in g2,26.47% in g3 and 54.41% in g4. majority of cases i.e. 60.29% in stage iv followed by 19.11% in stage i,10.29% each in stage ii and stage iii. cd24 immuno staining positivity was seen in majority of grade 3 and grade 4. in grade 3,38.88% showed moderate and 22.22% strong immuno reaction. amongst grade 4,40.54% showed moderate and 13.51% strong positive. variable immuno pattern was observed according to tnm staging. in stage i,46.15% showed moderate and 7.69% strong positivity,while in stage ii,57.14% were negative for saining. in stage iii,42.85% were negative while 28.57% each showed moderate and strong staining. majority of cases in stage iv i.e. 48.78% were negative for staining while 34.14%,17.07% showed moderate and severe cd24 immuno staining. conclusion: majority of grade i retinoblastoma were in tnm stage i & ii and mostly were immuno negative. lymph node and distant metastatic cases were 75% in g4 and 25% in g3,all of them showed moderate to strong immunoreactivity. these results showed that cd24 expression may be a marker of poor prognosis in retinoblastoma. whereas tnm staging of retinoblastomas with cd24 expression had varying pattern and showed no significant correlation between them. © 2016,professional medical publications. all rights reserved.