Increase in activity of Na+,K+-ATpase by porphyrin compounds as treatment for dysnatremias caused by diabetes mellitus

Objective: the aim of this study was to test the action of porphyrin compounds,tetraphenylporphine sulfonate (tpps),5,10,15,20-tetrakis (4-sulfonatophenyl) porphyrinato iron(iii) chloride (fetpps) and 5,10,15,20-tetrakis (4-sulfonatophenyl) porphyrinato iron(iii) nitrosyl chloride (fenotpps),on na+,k+ -atpase of cell membrane of erythrocytes. methods: enzymatic assays,measuring the amount of inorganic phosphate produced,were used to estimate the activity of na+,k+-atpase. results: the results show that porphyrin compounds exert an insulin-like effect on na+,k+-atpase. they act by increasing the activity of the membrane-bound enzyme. conclusion: all the three porphyrin compounds increased the activity of erythrocyte na+,k+-atpase. the exact mechanism of action of these compounds is not clear. © 2016,professional medical publications. all rights reserved.