Role of bevacizumab in the prevention of early postoperative haemorrhage after 25-gauge microincision vitrectomy surgery

Objective: to evaluate the effect of preoperative intravitreal bevacizumab injection on the incidence of postoperative haemorrhage and visual prognosis,in patients undergoing 25-gauge micro incision vitrectomy surgery (mivs) for diabetic vitreous haemorrhage. methods: one hundred and twenty two eyes of 122 patients of diabetic retinopathy of both genders and aged over 18 years,who presented with non-resolving vitreous haemorrhage were enrolled for this study. all patients received an intravitreal injection of 1.25 mg/0.05 ml bevacizumab (avastin) which was followed one week later by 25-gauge sutureless micro incision vitrectomy surgery. main outcomes measured were best corrected visual acuity (bcva) assessed with logmar and post-operative vitreous haemorrhage. follow ups were up to six months post-operatively. ibm spss 21 was used for data analysis. result: a total of 122 patients were included; 78 (63.9%) males and 44 (36.1%) females. mean age at the time of surgery was 51.4 ± 13.66 years. the mean preoperative bcva was 1.64 ± 0.427 logmar which improved to 0.57 ± 0.253 logmar at 12 months post-operatively (p-value < 0.001). recurrent vitreous haemorrhage was seen in four patients (3.28%). one1 week before 25-gauge vitrectomy helps to reduce the incidence of early post-vitrectomy haemorrhage in diabetic patients. © 2016,professional medical publications. all rights reserved.