Comparison of effects of propofol and isosorbide dinitrate during rewarming on cardiopulmonary bypass

Objectives: comparison of effects of propofol and isosorbide dinitrate during rewarming on cardiopulmonary bypass in patients undergoing coronary artery bypasses grafting. methods: it was randomized prospective clinical trial. one hundred and twenty patient (120) undergoing cabg surgery were included in this study. group-i (study group,n=60): in which only propofol infusion used during rewarming and group-ii (control group,n=60) in which isosorbide dinitrate and propofol infusion combination was used during rewarming. the data was entered and analyzed through spss version 19. independent sample t-test and chi-square test were used for data analysis. p value of ≤ 0.05 was taken as significant. results: mean arterial pressures during rewarming were 63.41±3.61 mmhg in propofol group versus 60.80±4.86 mmhg in control group (p-value 0.001). core temperature on weaning from cardiopulmonary bypass was 37.11±0.49 ºc in propofol group and 37.00±0.18 ºc in control group. after drop in core temperature was little more in propofol group (1.02±0.36 oc) versus 0.96±0.37 ºc in control group but this difference was not statistically significant (p-value 0.41). mean ventilation time after surgery in propofol group was 4.65±0.65 hours versus 5.03±0.81 hours in control group (p-value 0.006). conclusion: propofol alone is capable of fulfilling the requirements of adequate rewarming during cardiopulmonary bypass and can produce more hemodynamic stability and early post-operative recovery. © 2016,professional medical publications. all rights reserved.