Prognostic significance of B7-H3 expression in patients with colorectal cancer: A meta-analysis

Objective: the co-stimulatory molecule b7-h3 plays an important role in prognosis of several malignancies. however,its prognostic value in clinic in patient with colorectal cancer (crc) is still controversial. this meta-analysis evaluated the relationship between b7-h3 expression and the outcomes of crc patients. methods: pubmed,google scholar,embase,cnki and wanfang database were searched for the studies on the relationship between the expression of b7-h3 and prognosis of crc patients. pooled odds ratios (ors) analysis with 95% confidence interval (95% cis) for lymph node metastasis,24-month overall survival and 72-month overall survival were performed mainly using review manager 5.0. results: six articles including 1,202 total crc cases were included for the meta-analysis. pooled analysis with fixed-effects model showed that b7-h3 expression had no relationship with lymphatic metastasis in crc patients (fixed-effects,or= 1.18; 95 % ci:0.87-1.61,p=0.28). however,b7h3 expression was associated with 24-month overall survival (fixed-effects,or=0.48,95% ci: 0.32-0.74,p<0.001) and 72-month overall survival (fixed-effects,or = 0.61,95% ci: 0.43-0.85,p< 0.01) in crc patients. conclusion: the co-stimulatory molecule b7-h3 expression is negatively associated with lymph node metastasis in crc. however,b7-h3 detection might be a feasible and effective means to predict the prognosis in crc patients. © 2016,professional medical publications. all rights reserved.