Effects of letrozole in combination with low-dose intramuscular injection of human menopausal gonadotropin on ovulation and pregnancy of 156 patients with polycystic ovary syndrome

Objective: to explore the effects of letrozole (le) in combination with low-dose intramuscular injection of human menopausal gonadotropin (hmg) on the ovulation induction and pregnancy of patients with polycystic ovary syndrome (pcos). methods: a total of 156 patients with pcos infertility were randomly divided into an le group,a clomiphene citrate (cc) group and an le + hmg group (n= 52). le and cc were orally taken according to the prescribed dosage on the 3rd-5th days of menstruation respectively,and 75 iu hmg was given through intramuscular injection. the ovulation induction parameters and pregnancy outcomes were observed. results: the number of ovulation cycle of le + hmg group was significantly higher than that of le group (x2=8.451,p<0.001). after injection of human chorionic gonadotropin,both endometrial thickness and number of mature follicles of le + hmg group were significantly higher than those of other two groups (p<0.001),and the daily estradiol (e2) level was also higher (q=4.531,p<0.05). the pregnancy rate of le + hmg group was 55.7%,which exceeded those of other two groups (compared to le group,x2=4.012,p<0.05). in le + hmg group,the average medication cycle of clinically pregnant patients was (2.9 ± 0.3) weeks,which was significantly shorter than those of cc and le groups (f=17.241,p<0.001). conclusion: the regimen using le in combination with low-dose intramuscular injection of hmg has satisfactory therapeutic effects on ovulation induction,short medication cycle and high clinical pregnancy rate,which is promising for treating patients with pcos infertility. © 2016,professional medical publications. all rights reserved.