Clinical analysis of five cases of AIDS-related non-hodgkin lymphoma

Objective: secondary malignancy is a major life-threatening complication facing patients afflicted with acquired immunodeficiency syndrome (aids). this study aimed to retrospectively review clinical features and treatment course of five patients with aids-associated non-hodgkin lymphoma (a-nhl) in jilin tumor hospital. methods: five a-nhl patients were retrospectively and consecutively hospitalized at our oncological unit between january 2012 and june 2014. all patients received pre-emptive highly active antiretroviral therapy (haart) and chemotherapy,and were subsequently followed up at the outpatient clinic. all five patients were male,aged 27-53 years,and afflicted with a-nhl involving upper jaw,right inguinal region,right-side gingiva,mediastinum,or right-side neck. histology showed diffuse large b-cell lymphoma (n = 3) or plasmablastic lymphoma (n = 2). results: two patients achieved complete remission after haart and chemotherapy,whereas other three patients required a second-line treatment,with two achieving stable disease and one dying within a follow-up period of 0.5-2 years. conclusion: the findings of the present study showed that a-nhl is a disease often diagnosed in the middle-to-late stages,with diverse clinical manifestations and short overall survival. in the cases reviewed in this study,haart in combination with standard dose or high-dose chemotherapy,haart and molecular targeted chemotherapy was administered,and these treatments proved to be effective for improving the prognosis of these patients. moreover,the cd4+ cell count was important for determining the prognosis of patients. © 2016,professional medical publications. all rights reserved.