Immune status of children with obstructive sleep apnea/hypopnea syndrome

Objective: we aimed to evaluate the immune status of children with obstructive sleep apnea/hypopnea syndrome (osahs). methods: fifty children with osahs having the symptoms of “snoring,mouth breathing and suffocating during sleep”,who were admitted in our hospital from may 2014 to may 2016,were randomly selected. another 52 healthy,age- and gender-matched children were enrolled as control subjects after taking informed consent. after admission,the peripheral venous blood was collected. t cell subsets and cytokines were analyzed by flow cytometry. immunoglobulin and complement levels were detected by immunoassay analyzer. results: the percentage of cd8+ t lymphocytes in children with osahs was (26.47 ± 1.52)% which was significantly higher than that of control group ((21.94 ± 1.92)%) (p<0.05). osahs group had a significantly lower cd4+/cd8+ ratio (1.24 ± 0.12) than that of control group (1.45 ± 0.11) (p<0.05). the two groups had similar percentages of cd3 + and cd4+ t lymphocytes (p>0.05). osahs group had significantly higher serum levels of il-4,il-6,il-10 and ifn-γ than those of control group (p<0.05),but their il-2 and tnf-a levels were similar (p>0.05). the serum iga and c3 levels of osahs group significantly exceeded those of control group (p<0.05),but their igg,igm and c4 levels were similar (p>0.05). conclusion: children with osahs had increased percentage of cd8+ t lymphocytes and decreased cd4+/cd8+ ratio,suggesting this group had poor immune function. increase in humoral immune-related indices il-4,il-6,il-10 and ifn-γ indicated the occurrence of oxidative stress and systemic inflammatory status. © 2017,professional medical publications. all rights reserved.