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Evaluation of the synergistic effect of a combination of colistin and tigecycline against multidrug-resistant acinetobacter baumannii
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نویسنده
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kaya i.a. ,guner m.d. ,akca g. ,tuncbilek s. ,alhan a. ,tekeli e.
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منبع
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pakistan journal of medical sciences - 2017 - دوره : 33 - شماره : 2 - صفحه:393 -397
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چکیده
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Objective: acinetobacter baumannii species cause nosocomial infections and can subsequently develop multidrug resistance (mdr). the objective of this study was to evaluate the susceptibility of a. baumannii to a novel combination of colistin and tigecycline,which may provide a faster and more efficacious treatment via a synergistic effect. methods: we included 50 mdr a. baumannii samples that were isolated in our clinics between 2009 and 2014. we used broth microdilution (bmd) and the e-test to evaluate the effects of colistin and tigecycline,and the e-test to assess the interaction of the colistin-tigecycline combination. the interaction between the two antibiotics was evaluated using the fractional inhibition concentration (fic) index and was classified as follows: fic≤0.5,synergistic; 0.5
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کلیدواژه
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Acinetobacter baumannii; Colistin; Multidrug resistance; Synergy; Tigecycline
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آدرس
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infectious diseases and clinical microbiology department,ankara numune education and research hospital,ankara, Turkey, tobb economics and technology university,medical school medical pharmacology department,ankara, Turkey, medical microbiology department,gazi university faculty of dentistry,ankara, Turkey, medical school infectious diseases and clinical microbiology department,ufuk university,ankara, Turkey, faculty of arts and science statistics department,ufuk university,ankara, Turkey, medical school infectious diseases and clinical microbiology department,ufuk university,ankara, Turkey
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Authors
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