Clinical effects of pulmonary surfactant in combination with nasal continuous positive airway pressure therapy on neonatal respiratory distress syndrome

Objective: to analyze the therapeutic effect of pulmonary surfactant (ps) in combination with nasal continuous positive airway pressure (ncpap) therapy on neonatal respiratory distress syndrome (nrds). methodology: forty-nine neonates who were diagnosed as nrds and admitted in our hospital from may 2014 to june 2015 were selected and divided into an observation group and a control group. the observation group was treated with ps and ncpap. the control group was treated only with ncpap. the clinical symptoms,pulmonary x-ray,arterial partial pressure of oxygen (pao2) and prognosis of the two groups were observed. results: twelve hours after treatment,the partial pressure of carbon dioxide and oxygenation index decreased significantly (p<0.05),and pao2 and ratio of arterial/pulmonary oxygen partial pressures increased significantly (p<0.05). pulmonary x-ray examination showed that 78.3% of the observation group and 53.8% of the control group were relieved 12-24 hour after treatment,between which the difference was statistically significant (p<0.05). the improvement rate of the observation group was significantly higher than that of the control group (82.6% vs. 57.7%,p<0.05),the incidence of complications was significantly lower in the observation group (p<0.05),and the average length of stay in the observation group was significantly shorter (p<0.05). conclusion: both methods effectively treated nrds,but ps in combination with ncpap better improved oxygenation,reduced mortality and incidence of complications. © 2017,professional medical publications. all rights reserved.