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Efficient Three-Component Synthesis of 3,4-Disubstituted Isoxazol-5(4H)-ones in Green Media
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نویسنده
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Kiyani Hamzeh ,Jabbari Morteza ,Mosallanezhad Asiyeh
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منبع
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jordan journal of chemistry - 2014 - دوره : 9 - شماره : 4 - صفحه:279 -288
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چکیده
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Several derivatives of 3,4-disubstituted isoxazol-5(4h)-ones were synthesized via a onepot, three-component cyclocondensation reaction of hydroxylamine hydrochloride, various aryl aldehydes and β-oxoesters. the process takes place in water at room temperature. tetrabutylammonium perchlorate (tbap), sodium oxalate or glycine act as catalysts in promoting this reaction. the merits of this method are its efficiency, simplicity, cleanness, greenness, easy work-up, high chemical yields, recyclability, avoidance of using organic solvents, as well as the relatively short reaction times.
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کلیدواژه
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Isoxazol-5(4H)-one; Catalyst; Green chemistry; Three-component synthesis
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آدرس
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damghan university, School of Chemistry, ایران, damghan university, School of Chemistry, ایران, damghan university, School of Chemistry, ایران
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Authors
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