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One-Pot Synthesis of 2-Alkyl/arylamino-6-chlorothieno[3,2-e]-1,3-thiazin-4-one
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نویسنده
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Abu-El-Halawa Rajab ,Haj Elhussin Imad Elddin ,Al-Refai Mahmoud ,Ibrahim Mohammad
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منبع
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jordan journal of chemistry - 2014 - دوره : 9 - شماره : 2 - صفحه:127 -133
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چکیده
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2-alkyl/arylamino-6-chlorothieno[3,2-e]-1,3-thiazin-3-one derivatives were prepared in one-pot synthesis by refluxing alky/arylisothiocyanates and 2,5-dichloro-3-thiophenecarboxamide. alternatively, these derivatives were prepared by the intramolecular cyclization of the deprotonated 2,5-dichloro-n-(alkyl/arylaminocarbonothioyl)thiophene-3-carboxamides, which were obtained by the reaction of the deprotonated 2,5-dichloro-3-thiophene-carboxamide with alky/arylisothiocyanates. the structures of the newly synthesized bicyclic derivatives, and their acyclic precursors, were confirmed based on microanalytical and spectral (ir, ms, and nmr) data.
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کلیدواژه
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Thieno[3 ,2-e]-1 ,3-thiazin-3-one; thiophene-3-carboxamides; isothiocyanates; intramolecular cyclization
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آدرس
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University of Al al-Bayt, Department of Chemistry, Jordan. Albaha University, Clinical Pharmaceutical College, Saudi Arabia, Al al-Bayt University, Chemistry Department, Jordan, University of Al al-Bayt, Department of Chemistry, Jordan, University of Al al-Bayt, Department of Chemistry, Jordan
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Authors
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