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Unexpected Reduction of C-Cl Bond to C-H Bond by Hydrazine- Mediated Reaction During the Synthesis of Alkylbenzimidazoles Derivatives
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نویسنده
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Mahdavi Behnam ,Rahimizadeh Mohammad ,Bakavoli Mehdi ,Rezaei-Seresht Esmail ,Fatemi Mohammad
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منبع
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jordan journal of chemistry - 2013 - دوره : 8 - شماره : 1 - صفحه:63 -69
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چکیده
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Acid-catalyzed cyclocondensation of 2-chloroacetic acid and 2-chloropropionic acid with somesubstituted o-phenylenediamines afforded the corresponding 2-(1-chloroalkyl)benzimidazoles.upon treatment with hydrazine hydrate, in order to obtain hydrazine-containing compounds assuitable precursors for construction of new heterocyclic systems, the latter compoundsunderwent an overall unexpected reduction of the c-cl bond to c-h bond in a sequence of sn2 followed by bonds (atom) rearrangment to furnish 2-alkylbenzimidazoles.
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کلیدواژه
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Reduction; Hydrazine; Diimide; o-Phenylenediamines; 2-alkylbenzimidazoles
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آدرس
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hakim sabzevari university, Faculty of Sciences, Department of Chemistry, ایران, ferdowsi university of mashhad, Faculty of Sciences, Department of Chemistry, ایران, ferdowsi university of mashhad, Faculty of Sciences, Department of Chemistry, ایران, hakim sabzevari university, Faculty of Sciences, Department of Chemistry, ایران, Azad University of Mashhad, Faculty of Sciences, Department of Chemistry, ایران
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Authors
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