Preparation and Antimicrobial Screening of Novel 2, 2-dichlorocyclopropane– cis-dicarbamates and Comparison to their Alkane and cis-Alkene Analogs

The search for more active antimicrobial agents is a persistent process. moreover, increasing prevalence of resistant miroorganisms to common antimicrobial agents ecessitates the search for new active compounds. to this end, we prepared a series of novel compounds containing both cis-gem-dichlorocyclopropane and aromatic carbamate moieties-some with mono and dichloro substitution 9a-f. for comparison purposes known and new compounds containing four carbon spacers, both alkane 7a-f and cis alkene 8a-f dicarbamate analogues were also prepared. all compounds were characterized by nmr, ftir and hr-ms spectrometry. the prepared compounds were screened against representative gram negative bacteria, yeast and gram positive bacteria. excellent trends for antimicrobial activity were observed mainly against gram positive bacteria. the cis-gem-dichlorocyclopropane spacer targets (series 9) exhibited the strongest activity with three out of the six compounds from series 9 having activity against (s. aureus 29213) that are stronger than that of commercial antibiotics tested. the excellent activity of the new system 9 against gram positive strains can provide a future promise in the search for new antimicrobial agent.