Short-term bone biochemical response to a single bout of high-impact exercise

Bone response to a single bout of exercise can be observed withbiochemical markers of bone formation and resorption. thepurpose of this study was to examine the response of bone biochemicalmarkers to a single bout of exhaustive high-impactexercise. 15 physically active young subjects volunteered toparticipate. the subjects performed continuous bilateral jumpingwith the ankle plantarflexors at 65 % of maximal ground reactionforce (grf) until exhaustion. loading was characterized byanalyzing the grf recorded for the duration of the exercise.venous blood samples were taken at baseline, immediatelyafter, 2h and on day 1 and day 2 after the exercise. procollagentype i amino terminal propeptide (p1np, marker of bone formation)and carboxyterminal crosslinked telopeptide (ctx, markerof bone resorption) were analyzed from the blood samples. ctxincreased significantly (32 %, p = 0.015) two days after theexercise and there was a tendensy towards increase seen inp1np (p = 0.053) one day after the exercise. a significant positivecorrelation (r = 0.49 to 0.69, p . 0.038) was observed betweenchange in p1np from baseline to day 1 and exercisevariables (maximal slope of acceleration, body weight (bw)adjusted maximal grf, bw adjusted grf exercise intensityand osteogenic index). based on the two biochemical boneturnover markers, it can be concluded that bone turnover isincreased in response to a very strenuous single bout of exhaustivehigh-impact exercise.