The effects of aerobic exercise intensity and duration on levels of brain- derived neurotrophic factor in healthy men

This study examined the combined effects of aerobic exercise intensity and duration on serum brain-derived neurotrophic factor (sbdnf) levels in healthy human adult males aged 18-25 years. forty five participants were randomly assigned to one of six exercise conditions based on varying intensity (80% or 60% of heart rate reserve,or control) and duration (20 or 40 min). vigorous (80% heart rate reserve,vig) and moderate (60% heart rate reserve,mod) exercise was carried out on cycle ergometers. control subjects remained seated and at rest during the exercise period. pre- and post-exercise blood draws were conducted and sbdnf measured. physical exercise caused an average ~ 32% increase in sbdnf levels relative to baseline that resulted in concentrations that were 45% higher than control conditions. comparing the six conditions,sbdnf levels rose consistently among the four exercise conditions (vig20 = 26.38 ± 34.89%,vig40 = 28.48 ± 19.11%,mod20 = 41.23 ± 59.65%,mod40 = 30.16 + 72.11%) and decreased consistently among the controls (con20 = -14.48 ± 16.50,con40 = -10.51 ± 26.78). vig conditions had the highest proportion of subjects that experienced a significant (≥10%) increase in sbdnf levels,followed by mod and control conditions. an analysis of modeled sbdnf integrals (area under the curve) demonstrated substantially greater values for vig40 and mod40 conditions compared to vig20 and mod20 conditions. collectively,these results demonstrate that neither duration (20 vs. 40 min) nor intensity (60 vs. 80% hr reserve) significantly affects the benefits of exercise if only the sbdnf increase at a single post-exercise time point is considered. however,when comparing either the probability of achieving a significant bdnf gain or the integral (i.e. the volume of circulating bdnf over time) the vig40 condition offers maximal benefits. thus,we conclude that the future study of aerobic exercise effects on bdnf-mediated neuroprotection should take the volume of bdnf release over time into account. © journal of sports science and medicine (2013).