Impact of Early Treatment With High-Dose Intravenous Immunoglobulin on Incidence of Kawasaki Disease Complications in Iranian Children

Objective: kawasaki disease (kd) occurs in five-year- old or younger children. this study aimed to evaluate the impact of high-dose intravenous immunoglobulin plus acetylsalicylic acid therapy on the prevention and treatment of coronary artery lesions and to evaluate the impact of high-dose acetylsalicylic acid (asa) on the hearing of the patients. materials and methods: in this retrospective cohort study, 31 patients with kd were followed from january 2012 to december 2015. the clinical, para-clinical, color doppler echocardiogram and audiometry results were evaluated. results: overall, seven cases (22.6%) developed coronary artery aneurysm (caa) in the acute phase of the disease, of whom only two still had caa at the end of the treatment (6%). one of the five children with caa recovery had a delay in the onset of treatment and one of two patients with persistent caa at the end of treatment was admitted within the first 10 days. there was no evidence-based abnormal liver biochemical test. none of the patients developed sensorineural hearing loss (snhl) on audiometry tests conducted before and after treatment. conclusion: recovery of coronary artery lesions was 71.43% after 28 days of the onset of treatment. the distribution of coronary artery aneurysm was not different in terms of the time of the treatment initiation (p-value = 0.371). none of the children had a sensorineural hearing loss (snhl) 48 hours and 4 weeks after treatment.