endometrial serous carcinoma arising from adenomyosis: a clinico-pathological insight

Objective: endometrial cancer (ec) is the most commonly diagnosed malignancy and has the second highest mortality rate among gynecological cancers. adenomyosis is wellknown for abnormal uterine bleeding and is a widely reported entity; however, an ec arising from the adenomyosis is a rare event; even rarer is the occurrence of serous endometrial carcinoma. case report: a 60year post menopausal female presented with post menopausal bleeding. subsequently, she underwent a hysterectomy, which showed atrophic and cystic endometrium with extensive adenomyosis and atypical endometrial glands, which are diffusely p53 positive with intervening negative benign and focally positive dysplastic endometrial glands. a final diagnosis of serous endometrial carcinoma arising from adenomyosis was rendered. in a table format, previously reported serous endometrial carcinoma arising cases from adenomyosis using pubmed search had been described. conclusion: serous endometrial carcinoma arising from adenomyosis (20 cases reported) and has a slightly more dismal prognosis than those deriving from the endometrial cavity. hence, this case report highlights the occurrence, rarity, and importance of such an entity.