Comparing the Effectiveness of Doing Intra-Uterine Insemination 36 and 42 Hours After Human Chorionic Gonadotropin (Hcg) Injection on Pregnancy Rate: A Randomized Clinical Trial

Objective: intrauterine insemination (iui) is an assisted conception technique that involves the deposition of a processed semen sample in the upper uterine cavity, overcoming natural barriers to sperm ascent in the female reproductive tract. hence, we compared the results of doing intra-uterine insemination 36 and 42 hours after human chorionic gonadotropin (hcg) hormone injection to achieve clinical and chemical pregnancy rates. materials and methods: one hundred and sixty infertile women with unexplained infertility participated in this clinical trial. they were divided into two groups: those who underwent iui 36 hours after hcg injection (control group), and those who underwent iui 42 hours after hcg injection (case group). statistical analyses were done using ibm-spss 25.0. and chi-square test were used for data analysis. results: the percentages of clinical and chemical pregnancies were significantly higher in the 42h group compared to the other group (p = 0.038 vs. p = 0.009, respectively). there was no significant difference regarding frequency of abortion, twin and ectopic pregnancies between the two groups (p > 0.05). conclusion: doing iui 42 hours after hcg injection can significantly increase chances of fertility compared to doing it 36 hours after hcg injection.