High Frequency of Fetal Loss in Fetuses With Normal Karyotype and Nuchal Translucency ≥ 3 Among the Iranian Pregnant Women

Objective: the purpose of this study was comparison of association of three main first trimester screening factors with pregnancy outcomes among iranian pregnant women. materials and methods: this prospective study was done during 2017-2019 years in qazvin, iran. to do so, a total of 1500pregnant women in first trimester were enrolled. at the first step, nuchal translucency (nt) was measured in 11-13 ± 5 week, then the serum pregnancy-associated plasma protein a (papp-a) and free-β-human chorionic gonadotropin (free-β-hcg) were measured in 12-14 weeks of gestation. pregnant women were followed up until the end of pregnancy for the complications of pregnancy such as intra-uterine growth retardation (iugr), intrauterine death (iufd), different types of fetal loss and preterm labor. results: the results showed that low levels of serum biomarkers had more association with pregnancy complications in comparison to high levels of them. significant association of iugr (p = 0.001), iufd (p = 0.032) and pre-term labor (p = 0.002) was shown in women with low serum levels of papp-a in comparison to low serum levels of free-β-hcg. significant high frequency of different types of fetal loss (iufd, abortion, elective termination) was shown in fetuses with n ≥ 3 in comparison to low levels of serum biomarkers (p = 0.001). conclusion: this study highlighted the importance of accurately interpreting the results of the first trimester of pregnancy screening which should be considered by primatologists for subsequent pregnancy care.